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Article in English | IMSEAR | ID: sea-90493

ABSTRACT

Marchiafava- Bignami disease is the symmetrical demyelination of the middle portion of the corpus callosum observed in people with chronic alcoholism. We report two male patients who had history of chronic alcoholism, different clinical presentation and MRI findings consistent with the diagnosis of Marchiafava-Bignami disease.


Subject(s)
Adult , Aged , Alcoholism/complications , Corpus Callosum/pathology , Humans , Magnetic Resonance Imaging , Male , Marchiafava-Bignami Disease/diagnosis , Paresis , Persistent Vegetative State , Risk Factors , Thiamine/therapeutic use , Vitamin B Complex/therapeutic use
5.
Article in English | IMSEAR | ID: sea-89291

ABSTRACT

Alkaptonuria is a rare disorder of metabolism caused by deficiency of homogentisic acid oxidase enzyme and characterized by triad of homogentisic aciduria (dark urine), relentlessly progressive arthritis and ochronosis. We have documented a case with typical features of alkaptonuria along with intramedullary calcification which has not been reported in the literature before.


Subject(s)
Alkaptonuria/diagnosis , Calcinosis/diagnosis , Disease Progression , Homogentisate 1,2-Dioxygenase , Homogentisic Acid , Humans , Male , Middle Aged , Ochronosis/physiopathology , Risk Factors
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